Genetics & Genomics

Abelson helper integration site gene functions in a variant of T cell lymphoma

Published in Gene Therapy Weekly, October 26th, 2006

Research published from Canada has documented evidence for an oncogenic role of Abelson helper integration site 1 (AHI-1) in Sezary syndrome (SS), a leukemic variant of human cutaneous T-cell lymphomas.

"AHI-1 is a novel gene frequently activated by provirus insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by gross perturbations in its expression in human leukemia cells, particularly in cutaneous T-cell lymphoma cell lines where increases in AHI-1 transcripts of 40-fold are seen.

"To test directly whether deregulated expression of AHI-1 contributes to their transformed properties,...

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Source: Gene Therapy Weekly (2006-10-26)

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