Published in Gene Therapy Weekly, October 26th, 2006
"AHI-1 is a novel gene frequently activated by provirus insertional mutagenesis in murine leukemias and lymphomas. Its involvement in human leukemogenesis is demonstrated by gross perturbations in its expression in human leukemia cells, particularly in cutaneous T-cell lymphoma cell lines where increases in AHI-1 transcripts of 40-fold are seen.
"To test directly whether deregulated expression of AHI-1 contributes to their transformed properties,...
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