Endocrinology

Insulin-like actions displayed by a naphthoquinone derivative

Published in Gene Therapy Weekly, October 26th, 2006

According to a study from Japan, a naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and Tyr phosphatases.

"The 1,4-naphthoquinone derivative, shikonin, has been shown to increase glucose uptake by adipocytes and myocytes with minor effects on protein tyrosine phosphorylation in the cells (Biochem Biophys Res Commun 292:642-651, 2002). The present study was performed to examine the mechanism of this action of shikonin," wrote K. Nigorikawa and colleagues, Hiroshima University.

"Shikonin inhibited the phosphatidylinositol 3,4,5-triphosphate (PtdIns-3,4,5-P-3)...

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Source: Gene Therapy Weekly (2006-10-26)

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