Enzymology

Ubiquitin-conjugating enzyme displays thiolester formation

Published in Gene Therapy Weekly, October 26th, 2006

Recent research from the United States has reported on the demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression.

"We recently identified a differentially expressed gene in implantation stage rabbit endometrium encoding a new member of the ubiquitin-conjugating enzyme family designated UBE2Q2 (also known as UBCi). Its unusually high molecular mass, novel N-terminus extension, and highly selective pattern of mRNA expression suggest a specific function in implantation.

"This study analyzes its relationship to the E2 ubiquitin-conjugating enzyme superfamily,...

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Source: Gene Therapy Weekly (2006-10-26)

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