Published in Gene Therapy Weekly, November 2nd, 2006
"An important step toward understanding the mechanism of the PrPC-to-PrPSc conversion is to elucidate the folding pathway(s) of the prion protein," wrote A.C. Apetri and colleagues, Case Western Reserve University.
"On the basis of stopped-flow measurements, we recently proposed that the prion protein folds via a transient intermediate formed on the submillisecond time scale, and mutations linked to familial diseases result in a pronounced increase in the population of this intermediate.
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