Genetics & Genomics
DNA microarray assesses isoniazid hepatotoxicity
Published in Gene Therapy Weekly, November 9th, 2006
"The antituberculous drug INH is acetylated by NAT2, and the frequency of INH-induced hepatotoxicity is determined by the NAT2 genotype. NAT2 genotyping is not done routinely in hospital laboratories because of its difficulty.
"Use of microarrays for research is becoming common and its expectations of clinical application are increasing. In this study, we attempted to develop an easier method of NAT2 genotyping for clinical use," wrote Y. Shimizu and colleagues,...
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Source: Gene Therapy Weekly (2006-11-09)
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