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Lymphedema

Secondary lymphedema improves after gene therapy stimulates lymphangiogenesis

Published in Gene Therapy Weekly, November 9th, 2006

Secondary lymphedema improves after gene therapy stimulates lymphangiogenesis.

"Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Treatment for this disabling condition remains limited and largely ineffective," investigators in Japan reported.

"The goal of the present study was to investigate the therapeutic efficacy of hepatocyte growth factor (HGF) in animal models of lymphedema. Immunofluorescent analysis demonstrated that canine primary lymphatic endothelial cells (cLECs) were positive for lymphatic-specific markers (vascular endothelial growth factor receptor-3,...

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