Prostate Cancer
Prostate cancer radiosensitivity increased by heat shock protein down-regulation
Published in Gene Therapy Weekly, November 9th, 2006
"In this study, we examined whether human Hsp27 is involved in the radiation sensitization induced by gamma radiation in cultured human prostate cancer cells," wrote S. Teimourian and colleagues, University of Tehran.
"We transfected DU145 cells with full length Hsp27 antisense cDNA to obtain viable cell lines which expressed reduced Hsp27. Selected individual clones were subjected to western blot analyses to confirm reduced expression of Hsp27.
"Hsp27 belongs to a family of abundant and ubiquitous stress proteins, the...
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Source: Gene Therapy Weekly (2006-11-09)
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