Endocytosis Cell Biology
Studies from College of Medicine, Department of Microbiology and Immunology have provided new data on endocytosis cell biology
Published in Gene Therapy Weekly, November 9th, 2006
New investigation results, "Adenovirus RID complex enhances degradation of internalized tumour necrosis factor receptor 1 without affecting its rate of endocytosis," are detailed in a study published in The Journal of General Virology. "The receptor internalization and degradation (RID) complex of adenovirus plays an important role in modulating the immune response by downregulating the surface levels of tumor necrosis factor receptor 1 (TNFR1), thereby inhibiting NF-kappaB activation. Total cellular content of TNFR1 is also reduced in the presence of RID, which can be inhibited by treatment with lysosomotropic agents," researchers in the United States report.
"In this...
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Source: Gene Therapy Weekly (2006-11-09)
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