Published in Gene Therapy Weekly, November 9th, 2006
"Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation," wrote H. Montero and colleagues, Universidad Nacional Autonoma de Mexico (UNAM).
"For the initiation of translation of most cellular mRNAs, the cap structure at the 5' end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3' end, is recognized by the poly(A)-binding protein (PABP).
"eIF4G is a scaffold protein that brings together...
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