Cancer Treatment
New findings from Canada and the United States in the area of cancer treatment detailed
Published in Gene Therapy Weekly, November 9th, 2006
Study 1: A study from Canada has reported on the effect of histone deacetylase (HDAC) inhibitor LAQ824 on antineoplastic action of 5-Aza-2'-deoxycytidine (Decitabine) on human breast carcinoma cells.
"Epigenetic silencing of tumor suppressor genes (TSGs) by aberrant DNA methylation and chromatin deacetylation provides interesting targets for chemotherapeutic intervention by inhibitors of these events," wrote A. Hurtubise and colleagues, University of Montreal.
"5-Aza-2'-deoxycytidine (decitabine, 5AZA-CdR) is a potent demethylating agent, which can...
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Source: Gene Therapy Weekly (2006-11-09)
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