Published in Gene Therapy Weekly, November 9th, 2006
"Multiple signaling pathways involving protein kinase C (PKC) have been implicated in the development of cardiac hypertrophy. We observed that a putative PKC inhibitor, PICOT, was upregulated in response to hypertrophic stimuli both in vitro and in vivo.
"This suggested that PICOT may act as an endogenous negative feedback regulator of cardiac hypertrophy...
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