Published in Gene Therapy Weekly, November 9th, 2006
Study 1: According to recent research from Australia, DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats.
"The transcription factor and immediate-early gene Egr-1 is widely viewed as a key upstream activator in a variety of settings within cardiovascular pathobiology. The role that Egr-1 plays in myocardial ischemia reperfusion (IR) injury is unknown," wrote R. Bhindi and colleagues, University of New South Wales.
"We hypothesized that Egr-1 upregulation is of pathophysiologic...
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