Published in Gene Therapy Weekly, November 9th, 2006
Study 1: According to recently published research from Japan, antioncogenic Chk2 kinase is regulated by the oncogenic Wip1 phosphatase.
"The antioncogenic Chk2 kinase plays a crucial role in DNA damage-induced cell-cycle checkpoint regulation. Here we show that Chk2 associates with the oncogenic protein Wip1 (wild-type p53-inducible phosphatase 1) (PPM1D), a p53-inducible protein phosphatase," wrote H. Fujimoto and colleagues, Kobe University.
"Phosphorylation of Chk2 at Thr68 (Thr68), a critical event for Chk2 activation,...
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