Gene Therapy
Research from University of California, AIDS Institute in the area of gene therapy published
Published in Gene Therapy Weekly, November 9th, 2006
Scientists discuss in "Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors" new findings in . "Specific, potent, and sustained short hairpin RNA (shRNA)-mediated gene silencing is crucial for the successful application of RNA interference technology to therapeutic interventions. We examined the effects of shRNA expression in primary human lymphocytes (PBLs) using lentiviral vectors bearing different RNA polymerase III promoters," scientists in the United States report.
"We found that the U6 promoter is more efficient than the H1 promoter for shRNA expression and for reducing expression of CCR5 in...
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Source: Gene Therapy Weekly (2006-11-09)
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