Published in Gene Therapy Weekly, November 9th, 2006
"We have constructed a lentiviral vector with expression limited to cells presenting active E2F-1 protein, a potential advantage for gene therapy of proliferative diseases. For the FE2FLW vector, the promoter region of the human E2F-1 gene was utilized to drive expression of luciferase cDNA, included as a reporter of viral expression.
"Primary, immortalized, and transformed cells were transduced with the FE2FLW vector and cell cycle alterations were induced with serum...
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