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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . November 16th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cancer Gene Therapy - Medulloblastoma gene therapy delivered by human neural stem cells

Genetics & Genomics - Alternative splicing regulator identified by an expression cloning strategy

Pain Management - Neuropathic pain alleviated by injection of antisense oligonucleotides

RNA Interference - RNA interference library based on nuclear receptor consensus sequences reported

Vector Development - Lentiviral in situ vector delivery enabled gene transfer into adult stem cells

Angiogenesis - New angiogenesis findings from Children's Hospital described

Cancer Gene Therapy - Data on cancer gene therapy discussed by researchers at Ruhr University, Institute of Microbiology and Hygiene

Cancer Gene Therapy - Recent studies from Swiss Federal Institute of Technology, Department of Chemistry and Applied Biosciences add new data to cancer gene therapy

Cancer Gene Therapy - Research from Center for Cancer Research in the area of cancer gene therapy published

Cancer Gene Therapy - Researchers from National Institutes of Health describe findings in cancer gene therapy

Cancer Gene Therapy - Scientists at University of Alabama, Gene Therapy Center release new data on cancer gene therapy

DNA Vaccines - Research on DNA vaccines described by scientists at West Virginia University, Department of Obstetrics and Gynecology

Gene Therapy - Data on gene therapy described by researchers at Cornell University, Department of Genetic Medicine

Gene Therapy - Data on gene therapy published by researchers at Pennsylvania State University, Department of Chemistry

Gene Therapy - Investigators at Hawaii Agriculture Research Center publish new data on gene therapy

Gene Therapy - Investigators at Peking University, Institute of Sports Medicine target gene therapy

Gene Therapy - Investigators at University of Minnesota, Institute for Molecular Virology publish new data on gene therapy

Gene Therapy - New gene therapy data have been reported by scientists at University of Arizona, Department of Molecular and Cellular Biology

Gene Therapy - New gene therapy research from Medical College of Wisconsin, Department of Microbiology and Molecular Genetics discussed

Gene Therapy - New gene therapy research from National Institute of Agrobiological Science, Department of Developmental Biology outlined

Gene Therapy - New gene therapy study findings have been reported by researchers at Maine Medical Center

Gene Therapy - New gene therapy study findings have been reported from Georgetown University, Department of Biochemistry

Gene Therapy - New gene therapy study findings have been reported from SAIC-Frederick, Inc.

Gene Therapy - Recent findings from University of California, Cardiovascular Research Institute highlight research in gene therapy

Gene Therapy - Reports outline gene therapy research from Kyowa Hakko Kogyo Co., Ltd.

Gene Therapy - Research from Cornell University, Department of Microbiology and Immunology yields new findings on gene therapy

Gene Therapy - Research from Nankai University, College of Life Sciences has provided new data on gene therapy

Gene Therapy - Research from University of Queensland, Division of Molecular Genetics and Development has provided new data on gene therapy

Gene Therapy - Research on gene therapy published by scientists at University of Georgia

Gene Therapy - Researchers at Searle, Department of Medicine release new data on gene therapy

Gene Therapy - Researchers from Naval Health Research Center, Research Department publish new studies and findings in the area of gene therapy

Gene Therapy - Researchers' work from Cardiff University, Department of Rheumatology focuses on gene therapy

Gene Therapy - Scientists at University of Innsbruck, Institute of Pharmacy publish research in gene therapy

Gene Therapy - Studies from Roche describe new findings in gene therapy

Gene Therapy - Study findings from Ohio State University, Center for Retrovirus Research broaden understanding of gene therapy

Gene Therapy - Study results from McGill University, McGill Cancer Center broaden understanding of gene therapy

Hepatocellular Cancer Prevention - New findings from Johns Hopkins University in the area of hepatocellular cancer prevention published

Hepatocellular Cancer Therapy - Studies from Sungkyunkwan University, Division of Gastroenterology yield new information about hepatocellular cancer therapy

Lymphoma Gene Therapy - Findings from Medical University of Vienna, Division of Oncology advance knowledge in lymphoma gene therapy

Prostate Cancer Therapy - Research reports from Cardiff University provide new insights into prostate cancer therapy

Quantitative PCR Assays - Researchers from University of Missouri, Department of Molecular Microbiology and Immunology provide details of new studies and findings in the area of quantitative PCR assays

Allergy & Immunology - Allergic asthma is not modulated by ADAM33

Allergy & Immunology - Structure and function of the long pentraxin PTX3 glycosidic moiety examined

Apoptosis - Apoptosis genes regulated by Wnt/beta-catenin pathway identified

Apoptosis - Beta-cell death is regulated by nuclear factor-KB

Apoptosis - Early apoptotic genes targeted in batch and fed-batch CHO cell cultures

Bladder Cancer - Macrophage cytotoxicity against bladder cancer cells involves cytokines

Brain Cancer - Glioma-produced extracellular matrix influences brain tumor tropism of neural stem cells

Breast Cancer - Vector-activated dendritic cell injection and chemotherapy suppresses breast cancer

Business & Finance - Enzo Biochem reports results for fiscal 2006 and fourth quarter

Business Update - Compugen discloses status of in silico-discovered therapeutic candidates

Business Update - D-Pharm to join NeuroNE Network of Excellence

Business Update - Dow Neurobiology Laboratories extends their MetaCore licenses from GeneGo

Business Update - Enzo Biochem acquires license to six key RNA amplification patents

Cancer Gene Therapy - Antitumor effect enhanced by vaccination with telomerase reverse transcriptase modified tumor cell

Cancer Gene Therapy - Cancer cell gene expression changes following human papillomavirus integration

Cancer Gene Therapy - Controlled suicide gene system selectively kills human umbilical vein endothelial cells

Cancer Gene Therapy - Hepatocarcinoma gene therapy inhibiting NF-kappa B results in apoptosis

Cancer Gene Therapy - Introgen: Advexin molecular targeted therapy is active in multiple cancers

Cancer Gene Therapy - Myeloid progeny cell cytoskeleton reconstituted by retroviral-aided gene transfer

Cancer Immunotherapy - Lentigen gets SBIR to evaluate lentiviral-engineered T cells for cancer immunotherapy

Cancer Prevention - Cancer preventive ellagic acid accumulates in digestive tract epithelial cells

Cancer Therapy - Biological functions of a possible tumor suppressor characterized

Cancer Therapy - Effect of protein loss on spontaneous gynecological tumor development clarified

Cancer Therapy - Liver cancer cell interferon-mediated inhibition varies in different cell lines

Cancer Vaccine - Tumor-associated antigen-specific DNA vaccine induces protective and therapeutic antitumor immunity

Carcinoid Tumors - Carcinoid tumors could potentially be treated by targeted inhibition of protein kinase D family

Cardiology - Neointimal growth after vascular injury requires protein kinase C

Cell Biology - Receptor-based mobilization of internal calcium assayed

Cell Physiology - Cell polarity and focal adhesion turnover regulated in migrating cells

Cell Physiology - Nucleoporin is required for nuclear protein export

Chronic Liver Disease - Fatty liver disease and liver cirrhosis role of adiponectin clarified

Critical Care Medicine - Response to recombinant factor VIIa predicted patients with severe hemorrhage

Dermatology - Fabry disease sympathetic skin responses improved by enzyme replacement therapy

Diabetes Control - Diabetic beta cells are destroyed by cytotoxic T cells

Diabetes Control - Diabetic nephropathy genetically controlled in a mouse model

Diabetes Pathogenesis - Insulin-like growth factor receptor functions in kinase phosphorylation

DNA Research - Duplex formation improves radiolabeled antisense DNA delivery in cell cultures

DNA Research - Horizontally acquired DNA identified by interpolated variable order motifs

DNA Research - Noncoding Y RNAs are required for human chromosomal DNA replication

DNA Research - Structure of T4 pyrimidine dimer glycosylase defined

Drug Development - Exelixis files IND application for XL281 anticancer compound

Endocrinology - Neuroendocrine cell type-specific expression of the chromogranin B gene defined

Enzymology - Ubiquitin ligases are found in a novel complex that is recruited to targets

Facilities - Texas Children's Hospital announces largest investment ever by single pediatric organization

Finance - Inovio Biomedical closes $15.25 million equity financing

Finance - Senesco Technologies announces completion of $2.3 million equity financing

Finance - Senesco Technologies reports fiscal 2006 $3,314,885 net loss compared to $2,978,918 in 2005

Gastroenterology - Contribution of carboxylesterase isozymes to intestinal hydrolase activity clarified

Gastroenterology - Sterol transfer reconstituted by half-transporters

Gene Repair - Knowledge of mechanisms of action at molecular level lacking for targeted gene repair

Gene Research - 454 Sequencing reveals a new pathway in RNA interference

Gene Therapy - Inovio gets $1.1M from U.S. DoD to apply gene delivery technology to biodefense-related vaccines

Gene Therapy Policy - Policymaking process in Japan for gene therapy is appraised

Genetics & Genomics - Expression profiling identifies pathways altered in cellular immortalization

Genetics & Genomics - Genomic identification of regions of unusual compositional properties reported

Helicobacter Pylori - Helicobacter protein expression correlates with gastric adenocarcinoma

Hepatitis B Virus - Hepatitis B antigens are targeted differentially by monoclonal antibodies

Hepatitis C Virus - Hepatitis C virus replication targeting achieved with a single lentiviral vector

Hepatoma - Morris hepatoma cell apoptosis genes are induced by angiopoietin overexpression

Hepatoma - Morris hepatoma growth and vascularization inhibited by troponin overexpression

HIV/AIDS Prevention - HIV-1 integrase activity inhibited by synthetic peptides

HIV/AIDS Testing - HIV protease inhibitors screened by cytotoxicity protection

Imaging - Imaging of caspase activation in apoptosis reported

Infectious Diseases - Fabry disease protects against enterohemorrhagic Escherichia coli

Infectious Diseases - Human brucellosis displays cytokine gene polymorphisms

Infectious Diseases - Infection-related intestinal epithelial tight junction integrity studied

Licensing Agreements - Clinical Data signs exclusive license for monoclonal antibody pharmacogenetic patent portfolio

Licensing Agreements - Debiopharm and Cambridge Antibody Technology to develop and market gastric carcinoma therapy

Lung Cancer - Non-small cell lung cancer treated using cytotoxic agents

Malaria -  Plasmodium falciparum soluble histo-aspartic protease partial characterized

Market Analysis - Discover applications of microarrays in pharmaceutical arena with new report

Market Analysis - Report urges integrating pharmacokinetic and pharmacodynamic concepts into biotech drug development

Mergers & Acquisitions - Inovio acquires rights to DNA vaccine licenses and intellectual property from Valentis

Mesothelioma Vaccine - Mesothelioma is targeted with infectivity-enhanced survivin/conditionally replicative adenoviruses

Muscular Dystrophy - Muscular dystrophy associated-protein emerin is phosphorylated on Ser 49 by protein kinase A

Nanotechnology - Nanoparticle system achieves RNA interference

Neuroscience - Axonal sensorimotor polyneuropathy is associated with leader peptide mutation

Neuroscience - Cultured hippocampal neuron glycosylation is altered by ethanol

Neuroscience - Drosophila odorant response requires nervous system expression of beta integrin gene

Neuroscience - Epilepsy-linked receptor function is alleviated by phenobarbital

Neuroscience - Juvenile neuronal ceroid lipofuscinosis autoantibody response patterned

Neuroscience - Kallikrein participates dynamically in traumatic spinal cord injury

Neuroscience - Neural progenitor proliferation increased by protein overproduction

Neuroscience - Neural regeneration protein is a neuronal survival-promoting factor

Neuroscience - Overstimulation of prion protein signaling pathways injures neuronal cells

Neuroscience - Selective action of ifenprodil at the N-methyl-D-aspartate receptor probed

Neuroscience - Tau protein sequential phosphorylation generates a filamentous epitope

Pancreatic Cancer Treatment - Early immunization promotes lifelong control of pancreatic tumor progression

Pancreatic Cancer Treatment - p53-derived peptide blocks pancreatic cancer cell growth

Patents - Dyadic granted patent for high-throughput screening of expressed DNA libraries in filamentous fungi

Personnel - Enzo Biochem appoints former Novartis Pharmaceutical executive president of Enzo Therapeutics

Proteomics - High abundance proteins profiled in cystic fibrosis lung epithelial cells

Proteomics - Protein computational design stereochemically optimized

Proteomics - Rab5 stimulates insulin receptor substrate-protein kinase interaction

Proteomics - Recombinant activin A purified using follistatin gene domain

Respiratory Medicine - Binding site for Moraxella catarrhalis protein identified

Rett Syndrome - Case School of Medicine professor discovers nerve cell defects caused by mental retardation gene

Spinal Cord Injury - Sangamo collaborator reports positive preclinical data from nerve regeneration program

Toxicology - Molecular targets against mustard toxicity identified

Transplant Medicine - CD4+ T cells stimulated by adenovirus peptides recognize cells infected with adenovirus

Vector Development - Integration profile of equine infectious anemia virus-based vectors is presented

Virology - Herpes simplex virus type 1 nuclear capsid egress reconstituted in vitro

Virology - Retrovirus involved in tumor progression studied in vivo

Virology - Virus invasion of host cells identities a novel role for caveolae

Angiogenesis - New angiogenesis research reported from St. Michael's Hospital, Division of Cardiology

Antisense Technology - Investigators at Miami University, Department of Zoology have published new data on antisense technology

Antisense Technology - New findings from State University of Campinas describe advances in antisense technology

Biochemistry - Data on biochemistry reported by researchers at University of Ferrara, Department of Biochemistry and Molecular Biology

Biotechnology - Reports summarize biotechnology research from Agricultural Biotechnology Center

Cancer Gene Therapy - Dankook University, Institute of Nanosensor and Biotechnology details research in cancer gene therapy

Cancer Gene Therapy - Data on cancer gene therapy published by researchers at Second Military Medical University

Cancer Gene Therapy - Data on cancer gene therapy reported by researchers at University of Texas, M.D. Anderson Cancer Center

Cancer Gene Therapy - Research conducted at Kyoto University has provided new information about cancer gene therapy

Cancer Gene Therapy - Research on cancer gene therapy detailed by scientists at Ordway Research Institute, New York State Department of Health

Cancer Gene Therapy - Researchers from National Cheng-Kung University, Institute of Clinical Medicine detail findings in cancer gene therapy

Cancer Gene Therapy - Scientists at University of Kuopio, Department of Biotechnology and Molecular Medicine describe research in cancer gene therapy

Cancer Gene Therapy - Scientists at Yamaguchi University, Department of Obstetrics and Gynecology detail research in cancer gene therapy

Gene Therapy - Findings from National Heart and Lung Institute, Faculty of Medicine in gene therapy reported

Gene Therapy - Research on gene therapy reported by scientists at National Institute for Longevity Science

Gene Therapy - Studies from Max Delbruck Center for Molecular Medicine further understanding of gene therapy

Microbiological Methods - Osaka University reports research in microbiological methods

Prodrugs - New prodrugs findings from University of Nottingham, Center for Integrated Systems Biology and Medicine described

RNA Research - Studies from University of Antwerp in the area of RNA research published

Angiology - Researchers in the United States, Taiwan and Germany zero in on angiology

Apoptosis - New apoptosis study findings have been reported from Canada and the United States

Apoptosis - New findings from the United States and United Kingdom describe advances in apoptosis research

Apoptosis - Research from Germany, the United States and Italy yields new apoptosis data

Breast Cancer - Recent findings in breast cancer described by researchers from University of Texas, U.S.

Breast Cancer - Reports from the United States and Greece add new data to breast cancer research

Breast Cancer - Reports outline breast cancer research from Wayne State University, U.S.

Cancer Treatment - New cancer treatment study findings reported from University of Texas, U.S.

Cancer Treatment - Research from University of Michigan, U.S., provides new data about cancer treatment

Cancer Treatment - Studies from Fourth Military Medical University, People's Republic of China, reveal new findings on cancer treatment

Cardiology - Research in the area of cardiology reported from the United States and United Kingdom

Cardiology - Studies in the area of cardiology reported from the United States, Switzerland and Germany

Genetics - Research from Innsbruck University, Austria, in the area of genetics discussed

Genetics - Study findings from University of Helsinki, Finland, provide new insights into genetics

Ischemia - Findings from Japan in ischemia research reported

Neurology - Studies in the area of neurology reported from Fudan University, People's Republic of China

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