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Cancer Gene Therapy

Medulloblastoma gene therapy delivered by human neural stem cells

Published in Gene Therapy Weekly, November 16th, 2006

According to recently published research from the United States, human neural stem cells (NSCs) target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression.

"Medulloblastoma, a malignant pediatric brain tumor, is incurable in about one third of patients despite multimodal treatments. In addition, current therapies can lead to long-term disabilities.

"Based on studies of the extensive tropism of neural stem cells (NSC) toward malignant gliomas and the secretion of growth factors common to glioma and medulloblastoma, we hypothesized that NSCs could target medulloblastoma and be used as a cellular...

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