Cancer Gene Therapy

Cancer cell gene expression changes following human papillomavirus integration

Published in Gene Therapy Weekly, November 16th, 2006

According to a study from Germany, gene expression profiles reveal an upregulation of E2F and downregulation of interferon targets by human papillomavirus type 18 (HPV18) but no changes between keratinocytes with integrated or episomal viral genomes.

"Persistent infections with HPV18 can result in the development of cervical cancer. HPV18 genomes persist extrachromosomally in low-grade and precancerous lesions but are always integrated in cervical cancers, and this might contribute to the progression of HPV18-induced lesions," wrote B. Karstensen and colleagues, Clinical University of Tubingen.

"To address whether integration induces additional...

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Source: Gene Therapy Weekly (2006-11-16)

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