Published in Gene Therapy Weekly, November 23rd, 2006
Study 1: According to a study from the United States, oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia (APL)-like disease.
"Most patients with APL express PML-RAR alpha, the fusion product of t(15;17)(q22;q11.2). Transgenic mice expressing PML-RAR alpha develop APL with long latency, low penetrance, and acquired cytogenetic abnormalities.
"Based on observations that 4% to 10% of APL patients harbor oncogenic ras mutations, we coexpressed oncogenic K-ras from its endogenous promoter with...
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