Published in Gene Therapy Weekly, November 23rd, 2006
"DM1, the most common muscular dystrophy in adults, is caused by an expanded (CTG)(n) tract in the 3' UTR of the gene encoding myotonic dystrophy protein kinase (DMPK) 1, which results in nuclear entrapment of the 'toxic' mutant RNA and interacting RNA-binding proteins (such as MBNL1) in ribonuclear inclusions.
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.