Gene Therapy
Investigators at School of Pharmacy target gene therapy
Published in Gene Therapy Weekly, November 30th, 2006
Researchers detail in "Development and characterisation of chitosan nanoparticles for siRNA delivery," new data in . "Gene silencing mediated by double-stranded small interfering RNA (siRNA) has been widely investigated as a potential therapeutic approach for diseases with genetic defects. The use of siRNA, however, is hampered by its rapid degradation and poor cellular uptake into cells in vitro or in vivo," scientists in London, the United Kingdom report.
"Therefore, we have explored chitosan as a siRNA vector due to its advantages such as low toxicity, biodegradability and biocompatibility. Chitosan nanoparticles were prepared by two methods of ionic cross-linking,...
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Source: Gene Therapy Weekly (2006-11-30)
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