Gene Therapy
Reports summarize gene therapy study results from Cancer Research Center
Published in Gene Therapy Weekly, November 30th, 2006
Investigators publish new data in the report "Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus. Common features of parvovirus capsids are open pores at the fivefold symmetry axes that traverse the virion shell. Upon limited heat treatment in vitro, the pores can function as portals to externalize VP1/VP2 protein N-terminal sequences which harbor infection-relevant functional domains, such as a phospholipase A(2) catalytic domain," researchers in Heidelberg, Germany report.
"Here we show that adeno-associated virus type 2 (AAV2)...
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Source: Gene Therapy Weekly (2006-11-30)
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