Researchers from University of Iowa, Roy J and Lucille A Carver College of Medicine detail findings in gene therapy

Investigators publish new data in the report "A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation." According to a study from the United States, "Using biochemical and imaging approaches, we examined the postendocytotic fate of the complex formed by human choriogonadotropin (hCG) and a constitutively active mutant of the human lutropin receptor (hLHR-L457R) found in a boy with precocious puberty and Leydig cell hyperplasia. After internalization, some of the complex formed by the hLHR-wild type (hLHR-wt) and hCG recycles to the cell surface, and some is found in lysosomes where the hormone is degraded."

...

Want to see the full article?

• Purchase this article for only $3.00