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Cancer Gene Therapy

Researchers from Second Military Medical University, Department of Gastroenterology describe findings in cancer gene therapy

Published in Gene Therapy Weekly, December 7th, 2006

Current study results from the report, "Antisense Smo under the control of the PTCH1 promoter delivered by an adenoviral vector inhibits the growth of human pancreatic cancer," have been published. "Hedgehog (Hh) signaling pathway is crucial in growth and patterning during embryonic development. Recent data have shown an association of its activation with cancer formation and maintenance," scientists writing in the journal Gene Therapy report.

"A ligand-dependent activation, where Hh components (SHH, PTCH1, Smo and GLi1) are aberrantly expressed with PTCH1 being a negative feedback regulator, is a newly identified mechanism for pancreatic carcinogenesis. In this...

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