RNA Research
Researchers from Brigham and Women's Hospital, and Department of Medicine detail findings in RNA research
Published in Gene Therapy Weekly, December 7th, 2006
Researchers detail in "Modeling CTLA4-linked autoimmunity with RNA interference in mice," new data in rna research. According to recent research from the United States, "The CTLA4 gene is important for T lymphocyte-mediated immunoregulation and has been associated with several autoimmune diseases, in particular, type 1 diabetes. To model the impact of natural genetic variants of CTLA4, we constructed RNA interference (RNAi) "knockdown" mice through lentiviral transgenesis."
"Variegation of expression was observed in founders but proved surmountable because it reflected parental imprinting, with derepression by transmission from male lentigenics. Unlike the...
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Source: Gene Therapy Weekly (2006-12-07)
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