Colon Cancer
Researchers from Integrated Cancer Prevention Center detail findings in colon cancer
Published in Gene Therapy Weekly, December 14th, 2006
New research, "Targeting the active beta-catenin pathway to treat cancer cells," is the subject of a report. According to a study from Israel, "The adenomatous polyposis coli or beta-catenin genes are frequently mutated in colorectal cancer cells, resulting in oncogenic activation of beta-catenin signaling. We tried to establish in vitro and in vivo models for selectively killing human cancer cells with an activated beta-catenin/T-cell factor (Tcf) pathway."
"We used a recombinant adenovirus that carries a lethal gene [p53-up-regulated modulator of apoptosis (PUMA)] under the control of a beta-catenin/Tcf-responsive promoter (AdTOP-PUMA) to selectively target human...
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Source: Gene Therapy Weekly (2006-12-14)
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