Cancer Gene Therapy
Research on cancer gene therapy discussed by scientists at University of Zurich, Department of Biochemistry
Published in Gene Therapy Weekly, December 21st, 2006
Research findings, "PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: effects on tumor targeting," are discussed in a new report. According to a study from Zurich, Switzerland, "A major goal in antibody design for cancer therapy is to tailor the pharmacokinetic properties of the molecule according to specific treatment requirements. Key parameters determining the pharmacokinetics of therapeutic antibodies are target specificity, affinity, stability, and size."
"Using the p185HER-2 (HER-2)-specific scFv 4D5 as model system, we analyzed how changes in molecular weight and valency independently affect antigen binding and tumor localization....
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Source: Gene Therapy Weekly (2006-12-21)
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