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Gene Therapy

Research on gene therapy discussed by scientists at Purdue University, Department of Biological Sciences

Published in Gene Therapy Weekly, December 28th, 2006

Investigators publish new data in the report "Inactivation of Bacillus anthracis spores in murine primary macrophages." According to recent research from the United States, "The current model for pathogenesis of inhalation anthrax indicates that the uptake and fate of Bacillus anthracis spores in alveolar macrophages are critical to the infection process. We have employed primary macrophages, which are more efficient for spore uptake than the macrophage-like cell line RAW264.7, to investigate spore uptake and survival."

"We found that at a multiplicity of infection (moi) of 5, greater than 80% of the spores of the Sterne strain containing only the pXO1 plasmid...

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