Hepatitis C Virus Gene Therapy
Researchers at MOGAM Biotechnology Research Institute have published new data on hepatitis c virus gene therapy
Published in Gene Therapy Weekly, January 4th, 2007
A new study, "Inhibition of hepatitis C virus gene expression by small interfering RNAs using a tri-cistronic full-length viral replicon and a transient mouse model," is now available. "HCV is an ideal target for siRNA as its genome, a single-stranded RNA, is translated into a single viral polyprotein and replicated into negative-stranded RNA. In the present study, we monitored the effects of 36 different small interfering RNAs (siRNAs) transcribed from a plasmid-derived expression system on the luciferase activities expressed from a full-length HCV replicon, to identify potent siRNA target sites," investigators in South Korea report.
"Delivery of nine selected siRNA...
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Source: Gene Therapy Weekly (2007-01-04)
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