Fusion Proteins
Reports outline fusion proteins research from Royal Free and University College
Published in Gene Therapy Weekly, January 18th, 2007
A report, "Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy," is newly published data in Glycobiology. According to recent research from London, the United Kingdom, "MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT). The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug."
"MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade. The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT. The...
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Source: Gene Therapy Weekly (2007-01-18)
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