HIV/AIDS Gene Therapy
Study results from University of Tokyo, Center for Experimental Medicine update understanding of HIV/AIDS gene therapy
Published in Gene Therapy Weekly, January 25th, 2007
Researchers detail in "Nuclear import of the preintegration complex is blocked upon infection by human immunodeficiency virus type 1 in mouse cells," new data in HIV/AIDS. According to a study from Tokyo, Japan, "Mouse cells do not support human immunodeficiency virus type 1 (HIV-1) replication because of host range barriers at steps including virus entry, transcription, RNA splicing, polyprotein processing, assembly, and release. The exact mechanisms for the suppression, however, are not completely understood."
"To elucidate further the barriers against HIV-1 replication in mouse cells, we analyzed the replication of the virus in lymphocytes from human CD4/CXCR4...
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Source: Gene Therapy Weekly (2007-01-25)
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