Cancer Gene Therapy

Research data from Korea Institute of Radiological and Medical Science update understanding of cancer gene therapy

Published in Gene Therapy Weekly, January 25th, 2007

Research findings, "Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5," are discussed in a new report. According to a study from Seoul, Korea, "Sensitization of cancer cells to TRAIL could improve the effectiveness of TRAIL as an anticancer agent. We explored whether TRAIL in combination with phytosphingosine could sensitize cancer cells to TRAIL."

"The combined treatment enhanced synergistic apoptotic cell death of Jurkat T cells, compared to TRAIL or phytosphingosine alone. Enhanced apoptosis in response to the combination treatment was associated with caspase-8 activation-mediated Bax and Bak...

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Source: Gene Therapy Weekly (2007-01-25)

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