Cancer Gene Therapy

Researchers from Lombardi Comprehensive Cancer Center, Department of Radiation Medicine detail findings in cancer gene therapy

Published in Gene Therapy Weekly, January 25th, 2007

A new study, "Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation," is now available. According to a study from the United States, "Raf-1 protein serine/threonine kinase plays an important role in ERK signal transduction pathway of cell survival and proliferation. Raf-induced transcriptional changes are dependent on phosphorylation/activation of ERK."

"However, regulation of phospho-ERK (p-ERK) via Raf transcriptome is as yet unknown. We report the initial characterization of BRCC3, a novel gene discovered previously by mRNA expression profiling in MDA-MB 231 human breast cancer cells treated with...

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Source: Gene Therapy Weekly (2007-01-25)

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