Cancer Gene Therapy
Researchers from Institute of Pharmacology and Toxicology detail findings in cancer gene therapy
Published in Gene Therapy Weekly, January 25th, 2007
A report, "Molecular basis for the antiproliferative effect of agmatine in tumor cells of colonic, hepatic, and neuronal origin," is newly published data in Molecular Pharmacology. According to a study from Bonn, Germany, "The aim of the present study was to challenge potential mechanisms of action underlying the inhibition of tumor cell proliferation by agmatine. Agmatine inhibited proliferation of the human hepatoma cells HepG2, the human adenocarcinoma cells HT29, the rat hepatoma cells McRH7777, and the rat pheochromocytoma cells PC-12."
"Inhibition of proliferation of HepG2 cells was associated with an abolition of expression of ornithine decarboxylase (ODC)...
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Source: Gene Therapy Weekly (2007-01-25)
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