Cancer Gene Therapy

Data on cancer gene therapy described by researchers at Hoshi University, Institute of Medicinal Chemistry

Published in Gene Therapy Weekly, February 1st, 2007

Investigators publish new data in the report "Combination of non-viral connexin 43 gene therapy and docetaxel inhibits the growth of human prostate cancer in mice. Docetaxel (DTX) is used for the treatment of advanced hormone refractory prostate cancer. Connexin 43 (Cx43) is a tumor suppressor gene, and transfection of the Cx43 gene increases sensitivity to several chemotherapeutic agents," scientists in Tokyo, Japan report.

"The objective of this study was to evaluate the effectiveness of combination therapy of Cx43-expressing plasmid DNA (pCMV-Cx43) and DTX both in vitro and in vivo using a non-viral vector in human prostate cancer PC-3 cells. Transfection of...

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Source: Gene Therapy Weekly (2007-02-01)

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