Gene Therapy
Researchers from University fur Bodenkultur Wien detail new studies and findings in the area of gene therapy
Published in Gene Therapy Weekly, February 1st, 2007
Fresh data on are presented in the report "The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes. In mammalian cells, the mannose 6-phosphate receptor pathway accounts for the transport of most soluble acid hydrolases to lysosomes. It is believed that dissociation of mannose 6-phosphate receptors and their ligands is entirely driven by the acidic environment in endosomal compartments," scientists writing in the Journal of Cell Science report.
"Indeed, pH-perturbing substances such as ammonium chloride and monensin have been shown to inhibit lysosomal enzyme targeting in cells that express both...
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Source: Gene Therapy Weekly (2007-02-01)
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