Cancer Gene Therapy

Researchers from Kyoto Prefectural University, Department of Urology discuss findings in cancer gene therapy

Published in Gene Therapy Weekly, February 1st, 2007

New investigation results, "Gene therapy with TRAIL against renal cell carcinoma," are detailed in a study published in Molecular Cancer Therapeutics. "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells. However, TRAIL is not toxic against most normal cells," investigators in Kyoto, Japan report.

"We have accordingly examined by in vivo electroporation whether TRAIL induces apoptosis in renal cell carcinoma. In addition, combination treatment with TRAIL and 5-fluorouracil (5-FU) against renal cell carcinoma was also investigated. The NC65 renal cell carcinoma line was used as a target. pCAGGS TRAIL was injected into the...

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Source: Gene Therapy Weekly (2007-02-01)

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