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Gene Therapy

Reports outline gene therapy study results from Kansai Medical University, Department of Ophthalmology

Published in Gene Therapy Weekly, February 8th, 2007

Investigators publish new data in the report "Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells. A prior report showed ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells in an in vitro model of gyrate atrophy of the choroid and retina. This study was intended to clarify the mechanism of ornithine cytotoxicity and to determine the responsible amino acid transporters," investigators in Osaka, Japan report.

"The mRNA expression of amino acid transporters in human telomerase reverse transcriptase (hTERT)-RPE cells was...

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