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Gene Therapy

Studies from National Taiwan University, Institute of Pathology further understanding of gene therapy

Published in Gene Therapy Weekly, February 8th, 2007

A new study, "L2dtl is essential for cell survival and nuclear division in early mouse embryonic development," is now available. "l(2)dtl (lethal (2) denticleless), is an embryonic lethal homozygous mutation initially identified in Drosophila melanogaster that produces embryos that lack ventral denticle belts. In addition to nucleotide sequence, bioinformatic analysis has revealed a conservation of critical functional motifs among the human L2DTL, mouse L2dtl, and Drosophila l(2)dtl proteins," scientists writing in the Journal of Biological Chemistry report.

"The function of the L2DTL protein in the development of mammalian embryos was studied using...

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