Cancer Gene Therapy
Reports outline cancer gene therapy study findings from Harvard University
Published in Gene Therapy Weekly, February 8th, 2007
New investigation results, "Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma," are detailed in a study published in Journal of Gastrointestinal Surgery. "The high mobility group A1 (HMGA1) proteins are overexpressed in pancreatic cancers. They are architectural nuclear proteins, which regulate expression of multiple genes implicated in the malignant phenotype," researchers in the United States report.
"In this study, we hypothesized that HMG A1 silencing will promote chemosensitivity in pancreatic adenocarcinoma. We studied highly malignant pancreatic adenocarcinoma cell lines (MiaPaCa2 and PANC1)....
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Source: Gene Therapy Weekly (2007-02-08)
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