DNA Vaccines
Veterinary Laboratories Agency reports research in DNA vaccines
Published in Gene Therapy Weekly, February 15th, 2007
A report, "The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes," is newly published data in Vaccine. "Five candidate genes from the Brucella melitensis 16M genome were selected. Eukaryotic expression plasmids encoding these antigens were constructed and expression was verified in vitro from transfected Cos7 cells," researchers in Addlestone, the United Kingdom report.
"Each vaccine was assessed for protective efficacy in a BALB/c mouse brucellosis infection model. From these experiments two protective DNA vaccines were identified: p-omp25 and p-ialB. The Omp25 antigen (BMEI1249) has...
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Source: Gene Therapy Weekly (2007-02-15)
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