Drug Development

Dual gene therapy suppresses lung cancer in preclinical test

Published in Gene Therapy Weekly, February 15th, 2007

Combination gene therapy delivered in lipid-based nanoparticles drastically reduces the number and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center reported in the Jan. 15 edition of Cancer Research.

Two tumor-suppressing genes given intravenously reduced cancer separately but had their most powerful effect when administered together, cutting the number of tumors per mouse by 75% and the weight of tumors by 80%.

"In cancer treatment we have combination chemotherapy, and we also combine different modes of therapy -...

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Source: Gene Therapy Weekly (2007-02-15)

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