Gene Therapy

Studies from Charite University reveal new findings on gene therapy

Published in Gene Therapy Weekly, February 15th, 2007

Fresh data on are presented in the report "Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40." According to recent research from Berlin, Germany, "Free fatty acids (FFA) cause a rise in cytosolic free Ca2+ ([Ca2+]i) and stimulate insulin release from pancreatic beta-cells. The G-protein coupled receptor GPR40 can be activated by medium-and long-chain FFA."

"We investigated a potential role for GPR40 in the generation of the FFA-induced Ca2+ signal and insulin secretion. [Ca2+]i was measured in primary mouse beta-cells and in INS-1 cells, and insulin secretion was assessed from INS-1 cells. GPR40...

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Source: Gene Therapy Weekly (2007-02-15)

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