Virology
Research data from Institute of Virology and Immunoprophylaxis update understanding of virology
Published in Gene Therapy Weekly, February 15th, 2007
Current study results from the report, "Silencing of natural interferon producing cell activation by porcine circovirus type 2 DNA," have been published. According to recent research published in the journal Immunology, "Porcine circovirus type 2 (PCV2) infection of natural interferon producing cells (NIPCs) impairs the induction of interferon (IFN)-alpha and tumor necrosis factor (TNF)-alpha by cytosine-phosphorothioate-guanine (CpG) oligodeoxynucleotides (ODNs), thereby preventing both their autocrine maturation and the paracrine maturation of myeloid dendritic cells (DCs). The present study shows that the PCV2-mediated inhibition of NIPCs was mediated by viral DNA, although it...
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Source: Gene Therapy Weekly (2007-02-15)
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