Published in Gene Therapy Weekly, February 15th, 2007
Study 1: A new study, "KRAB can repress lentivirus proviral transcription independently of integration site," is now available. "The KRAB transcriptional repressor domain, commonly found in zinc finger proteins, acts by inducing the formation of heterochromatin. We previously exploited this property to achieve drug-regulated transgenesis and knock down by combining doxycycline-controllable KRAB-containing fusion proteins and lentiviral vectors," scientists writing in the Journal of Biological Chemistry report.
"Here, we asked whether KRAB-induced repression is...
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