Gene Therapy
Findings from University of Tokyo, Department of Orthopaedic Surgery advance knowledge in gene therapy
Published in Gene Therapy Weekly, February 22nd, 2007
Data detailed in "Erk pathways negatively regulate matrix mineralization" have been presented. According to recent research published in the journal Bone, "Skeletal mineralization is an important step regulating the mechanical properties of the calcified tissues, but molecular events underlying mineralization still remain elusive. We examined the role of extracellular signal-regulated kinase (Erk) pathways in matrix mineralization of osteogenic cells both in vitro and in vivo."
"Matrix mineralization by preosteocytic MLO-A5 cells and osteoblastic MC3T3-E1 cells was increased by either PD98059 Mek inhibitor treatment or adenovirus vector-mediated dominant negative...
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Source: Gene Therapy Weekly (2007-02-22)
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