Gene Therapy
Studies from University of California in the area of gene therapy described
Published in Gene Therapy Weekly, February 22nd, 2007
New research, "Diels-Alder ribozyme catalysis: a computational approach," is the subject of a report. According to recent research from the United States, "A computational comparison of the Diels-Alder reaction of a maleimide and an anthracene in water and the active site of the ribozyme Diels-Alderase is reported. During the course of the catalyzed reaction, the maleimide is held in the hydrophobic pocket while the anthracene approaches to the maleimide through the back passage of the active site."
"The active site is so narrow that the anthracene has to adopt a tilted approach angle toward maleimide. The conformation of the active site changes marginally at different...
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Source: Gene Therapy Weekly (2007-02-22)
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