Cancer Gene Therapy
Researchers from Erasmus University, Department of Neurology report on findings in cancer gene therapy
Published in Gene Therapy Weekly, February 22nd, 2007
Researchers detail in "Human adenovirus type 35 vector for gene therapy of brain cancer: improved transduction and bypass of pre-existing anti-vector immunity in cancer patients," new data in cancer. "Clinical trials in malignant glioma have demonstrated excellent safety of recombinant adenovirus type 5 (Ad5) but lack of convincing efficacy. The overall low expression levels of the Coxsackie and Adenovirus receptor and the presence of high anti-Ad5-neutralizing antibody (NAb) titers in the human population are considered detrimental for consistency of clinical results," scientists in Netherlands report.
"To identify an adenoviral vector better suited to infect primary...
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Source: Gene Therapy Weekly (2007-02-22)
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