Gene Therapy
Researchers from University of Alabama, Department of Pathology describe findings in gene therapy
Published in Gene Therapy Weekly, March 1st, 2007
Current study results from the report, "Notch1 augments intracellular trafficking of adeno-associated virus type 2," have been published. "We report here the significance of the Notch1 receptor in intracellular trafficking of recombinant adeno-associated virus type 2 (rAAV2). RNA profiling of human prostate cancer cell lines with various degrees of AAV transduction indicated a correlation of the amount of Notch1 with rAAV transgene expression," scientists writing in the Journal of Virology report.
"A definitive role of Notch1 in enhancing AAV transduction was confirmed by developing clonal derivatives of DU145 cells overexpressing either full-length or...
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Source: Gene Therapy Weekly (2007-03-01)
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