Gene Therapy

Study findings from University of Technology provide new insights into gene therapy

Published in Gene Therapy Weekly, March 8th, 2007

Research findings, "Cocksfoot mottle virus P1 suppresses RNA silencing in Nicotiana benthamiana and Nicotiana tabacum," are discussed in a new report. "The Sobemovirus genome consists of positive sense, single-stranded polycistronic RNA. The 5'-terminal ORF, encoding the protein P1, is its most variable region," investigators in Tallinn, Estonia report.

"Sobemoviral P1 has been described as dispensable for replication but indispensable for systemic infection. The P1 of Rice yellow mottle virus-Nigerian isolate (RYMV-N) is the only RNA silencing suppressor reported for sobemoviruses until now. Using an agrobacterium-mediated transient assay, we demonstrate here that P1...

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Source: Gene Therapy Weekly (2007-03-08)

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